网络中心性驱动的TOPSIS方法优先考虑癌症治疗目标
Chandramohan Nithya1, Neelesh Babu Thummadi2, P Manimaran2
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India.
这项研究使用基于网络的方法确定了26个高优先级的癌症基因. 五个新型基因 (NXF1,CDC5L,MOV10,EP300,CUL7) 显示出潜在的潜力,作为精密瘤学的未开发的治疗标.
科学领域:
- 瘤学和生物信息学
- 系统生物学 系统生物学
- 基因组学就是基因组学.
背景情况:
- 癌症仍然是一个重大的全球健康挑战,需要发现新的治疗点.
- 蛋白与蛋白相互作用 (PPI) 网络对于理解复杂的生物系统和识别潜在的药物点至关重要.
研究的目的:
- 建立一个高可信度的癌症PPI网络,并确定新的,高优先级的治疗点.
- 评估各种癌症类型中已识别的候选基因的预后意义.
主要方法:
- 癌症PPI网络的构建,包含2564种蛋白质和20747种相互作用.
- 应用TOPSIS多标准决策方法来对基因重要性进行排名.
- 使用TCGA数据集进行药物向映射,基因本体学 (GO),KEGG通路丰富和生存分析.
主要成果:
- 确定了26个高优先级的癌症基因,其中21个与现有的药物有关.
- 五个基因 (NXF1,CDC5L,MOV10,EP300,CUL7) 成为尚未探索的目标.
- 在多种癌症类型中,对CDC5L,EP300,MOV10,CUL7和NXF1具有显著的预后作用.
结论:
- 综合性TOPSIS网络框架有效地识别了已知的和新的癌症治疗目标.
- 这五个尚未探索的基因需要进一步的实验验证,以便在精密瘤学中开发潜在的治疗方法.
- 这种方法为扩大癌症疗法领域提供了一个强有力的战略.
更多相关视频
09:33Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
相关概念视频
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Targets for Drug Action: Overview
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
