睡眠障碍与循环炎症标记在抑郁症和双相情感障碍中的关联:系统性审查和元分析
Valeria Fiori1, Caterina Lombardo1, Andrea Ballesio1
1Department of Psychology, Sapienza University of Rome, Italy.
Sleep medicine
|December 31, 2025
概括
睡眠障碍与严重抑郁症 (MDD) 中较高的炎症标志物有关. 这一系统性审查发现,MDD患者的睡眠不足和高C反应蛋白 (CRP) 之间存在显著的关联,这表明睡眠与免疫之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 大型抑郁症 (MDD) 和双相情感障碍 (BD) 中睡眠障碍和炎症之间的关系仍在争论中.
- 周围的前炎性标志物越来越多地与情绪障碍的病理生理学有关.
研究的目的:
- 在MDD或BD的成年人中,系统地审查和元分析睡眠障碍和外周炎症前标记之间的相关性.
- 研究这些疾病的病理生理学中的潜在睡眠免疫交叉对话.
主要方法:
- 按照PRISMA指南进行的系统审查和元分析,在PROSPERO.中注册.
- 在多个数据库 (PubMed,Scopus,PsycInfo,Web of Science,MEDLINE,CINAHL) 进行了搜索,截至2025年1月.
- 包括21项研究 (13项元分析) 涉及5261名参与者.
主要成果:
- 在MDD患者中,主观睡眠障碍与聚合的炎症标志物 (r=.12,p<.001) 有显著的关联.
- 具体来说,睡眠障碍与MDD中C反应蛋白 (CRP) 水平 (r=.08,p=.012) 相相关.
- 对于特定的白细胞间蛋白 (IL-6,IL-1β,IL-8) 或TNF-α,没有发现显著的关联;对于BD元分析,数据不足.
结论:
- 研究结果表明,在MDD的病理生理学中,有潜在的睡眠-免疫交叉对话.
- 睡眠障碍和炎症之间的关联需要进一步研究情绪障碍.
- 结果应根据显著的元分析异质性进行解释.
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