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Cnidium monnieri水性提取物对小中Eimeria tenella感染的抑制作用

Yanchun Wang¹, Haixia Han¹, Qiang Zhang¹

¹College of Veterinary Medicine, Jilin Agricultural University, Changchun 130118, China.

Poultry science

|December 31, 2025

概括

Cnidium monnieri水性提取物 (CMAE) 显示出作为天然抗菌剂对肉中的Eimeria tenella的承诺. 它有效地减少肠道损伤,调节免疫反应,并抑制炎症途径.

科学领域:

兽医寄生虫学兽医寄生虫学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

埃梅里亚氏菌会导致 brojlers 中的 cecal coccidiosis,导致严重的经济损失.
对化学抗菌剂的耐药性需要开发安全,天然的替代品.
昆 (Cnidium monnieri (L.) Cusson) 具有抗炎,抗菌和免疫调节的特性.

研究的目的:

为了评估Cnidium monnieri水性提取物 (CMAE) 对Eimeria tenella的抗菌疗效.
阐明CMAE在体内和体外的作用机制.
为使用CMAE作为天然抗菌剂提供科学依据.

主要方法:

在体内对四组肉进行研究:对照,感染E. tenella,E. tenella + CMAE和E. tenella + diclazuril.
部组织的组织病理学分析和血清分析 (ELISA) 检测免疫标记物.
对细胞因子的基因表达分析 (qPCR) 和信号通路 (NF-κB) 的蛋白质分析 (西方斑).
流细胞测量以评估T细胞种群 (CD4+/CD8+).

主要成果:

CMAE显示出适度的抗菌作用 (ACI 161.5),与迪克拉祖里尔相美.
组织病理学显示,在CMAE治疗组中,状细胞的长度增加,炎症细胞透减少.
CMAE显著调节了细胞因子表达 (下调的促炎,上调的抗炎) 和抑制了NF-κB通路激活.
幽默免疫力 (IgA,IgM) 和细胞免疫力 (CD4+/CD8+T细胞比) 通过CMAE治疗得到增强.

结论:

在肉中,CMAE有效地减轻了Eimeria tenella引起的肠损伤.
抗菌机制涉及抑制NF-κB通路和平衡细胞因子表达.
CMAE增强了幽默和细胞免疫力,支持其作为天然抗菌剂的潜力.

关键词:

在Cnidium monnieri的水性提取物.埃梅里亚天尼拉 (Eimeria tenella) 是一种植物.在 NF-κBB 中.

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