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早期的P2X7受体激活减轻新生儿B组链球菌感染的严重程度和长期的神经发育障碍

Sales Fialho¹, Irina Amorim², Clara Quintas³

¹Laboratory of Immunology, Department of ImmunoPhysiology and Pharmacology, ICBAS - School of Medicine and Biomedical Sciences - University of Porto, Porto, Portugal.

International immunopharmacology

|December 31, 2025

概括

在新生小鼠中激活P2X7受体 (P2X7R) 可对抗B组链球菌 (GBS) 感染,降低死亡率并预防长期脑损伤和认知缺陷.

科学领域:

神经免疫学神经免疫学
新生儿败血症新生儿败血症
传染性疾病传染性疾病

背景情况:

新生儿B组链球菌 (GBS) 感染导致显著的死亡率和神经发育问题.
失调的免疫反应和神经炎症使GBS败血症治疗复杂化.
在感染期间,P2X7受体 (P2X7R) 在炎症和神经炎症过程中至关重要.

研究的目的:

研究P2X7R调制对新生儿GBS感染中的免疫和神经元功能障碍的影响.
在新生儿GBS败血症模型中评估P2X7R激活或阻断的治疗潜力.

主要方法:

新生小鼠从出生后的第1天到第4天接受了P2X7R激活剂 (Bz-ATP) 或抗剂 (A740003) 的治疗.
评估的生存率,细菌传播,细胞因子 (TNF-α,IL-1β,IL-10),中性粒细胞招募,质激活,大脑病理和神经发育结果.
在成年期评估长期的认知和焦虑类行为.

主要成果:

激活P2X7R显著改善了生存率,减少了疾病的严重程度,并减少了细菌负担.
免疫反应从抗炎性 (IL-10) 转变为促炎性 (TNF-α),增强中性粒细胞的招募.
激活P2X7R可以防止GBS引起的脑损伤,保护海马神经元,改善长期的认知功能和焦虑水平.
P2X7R封锁没有提供保护.

结论:

早期P2X7R激活有效地打击新生儿GBS死亡率,并预防长期的神经发育障碍.
准P2X7R代表了一种潜在的神经免疫治疗策略,用于改善早期感染后的结果.

关键词:

类似焦虑的行为.认知表现认知表现 B组的链球菌.免疫调节免疫调节新生儿感染新生儿感染.神经发育障碍神经发育障碍神经炎症是一种神经炎症.这是一个P2X7受体.

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