对新生胚胎转移试管婴儿周期中黄质期支持的孕激素注射途径的网络元分析
Georg Griesinger1, Qian Wang2, Elena Labarta3
1Department of Gynecological Endocrinology and Reproductive Medicine, University Hospital of Schleswig-Holstein, Luebeck 23552, Germany.
Reproductive biomedicine online
|December 31, 2025
概括
口服和肌肉内孕激素的使用途径可以改善体外受精 (IVF) 的结果,特别是临床怀孕和活产率. 需要进一步的研究来证实质阶段支持 (LPS) 的这些发现.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 药理动力学 药理动力学
- 在体外受精 (IVF)
背景情况:
- 孕激素的施用途径会影响试管婴儿中形阶段支持 (LPS) 的药理动力学和疗效.
- 目前的ESHRE指南建议在胚胎移植后的LPS中使用各种孕激素途径.
研究的目的:
- 评估不同孕激素施用途径在新鲜试管婴儿周期中对临床妊娠率 (CPR) 和活产率 (LBR) 的相对有效性.
- 提供基于证据的见解,以优化试管婴儿中的孕产妇LPS.
主要方法:
- 一项系统性审查和对已发表的随机对照试验 (RCT) 的网络元分析,比较LPS的孕激素.
- 纳入标准集中在新鲜的试管婴儿周期,特定的孕激素和CPR/LBR结果上.
- 排除对冷解转移或非孕原性LPS的研究.
主要成果:
- 与安慰剂相比,口服药物显示CPR在统计学上显著增加.
- 口服和肌肉内路线显示,与安慰剂相比,LBR在统计学上有显著的改善.
- 阴道和皮下途径没有显示出统计学上显著的LBR改善.
结论:
- 口服和肌肉内孕激素途径可能为改善试管婴儿结果提供更高的疗效.
- 由于重叠的置信区间,关于临床相关的优越性仍然存在不确定性.
- 需要进行进一步的研究,以最终确定在新试管婴儿周期中为LPS的最佳孕激素注射途径.
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