与256名患有先天性多发性关节炎的儿童的功能性移动性相关的因素:一个多中心横截面研究
Ahlam Zidan1, Laurie Snider2, Emmanouil Rampakakis3
1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada; Shriners Hospitals for Children, Montreal, Quebec, Canada.
Archives of physical medicine and rehabilitation
|December 31, 2025
概括
患有多重先天性关节位症 (AMC) 的儿童的功能性移动性受到关节参与和社会经济因素的重大影响. 有针对性的康复策略对于改善这一群体的结果至关重要.
科学领域:
- 整形医学和康复医学 整形医学和康复医学
- 儿科肌肉骨疾病 儿科肌肉骨疾病
- 功能移动性评估的功能移动性评估
背景情况:
- 关节缩多重先天性 (AMC) 是一种罕见的疾病,其特征是多重关节收缩,可能影响功能移动性.
- 关于AMC儿童,青少年和年轻人的综合功能移动状态和相关因素的研究有限.
研究的目的:
- 在被诊断患有AMC的5至21岁的大群个体中表征功能性移动性.
- 确定与功能性流动性结果相关的临床 (例如,联合参与,AMC亚型) 和环境 (例如,社会经济) 因素.
主要方法:
- 一个多站点,横截面研究涉及256名参与者与AMC在八个儿科整形医院.
- 使用儿童功能独立度量 (WeeFIM) 和吉莱特功能评估问卷 (FAQ) 评估功能移动性.
- 多变量模型分析了流动性结果与围产期,临床和环境因素之间的关联.
主要成果:
- 中枢神经系统/综合症和骨质疏松性AMC亚型的WeeFIM分数和FAQ水平与远端关节结症 (DA) 相比显著较低.
- 增加关节的参与,特别是膝盖的关节,以及围产期关节收缩与较差的移动性密切相关.
- 父母失业和更高的外科手术负担对功能移动性结果产生了负面影响.
结论:
- 这项研究代表了迄今为止调查AMC功能移动性的最大队列.
- 鉴定的临床和社会经济因素为制定个性化康复策略提供了宝贵的见解.
- 量身定制的干预措施可能会增强功能性流动性,并改善AMC患者的整体结果.
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