基于任务的fMRI和神经心理学洞察力对双相情感障碍中的记忆和注意力:系统性审查
Peyman Mardani1, Farzaneh Ramezani2, Giulia Cattarinussi3
1Department of Psychology and Counseling, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Journal of affective disorders
|December 31, 2025
概括
功能性MRI研究表明,双相情绪障碍 (BD) 中大脑激活的改变与认知缺陷有关. 这些神经模式可能反映真实世界的认知功能,但需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 双极性障碍 (BD) 与记忆和注意力障碍有关.
- 功能磁共振成像 (fMRI) 研究显示,BD中神经回路发生变化.
研究的目的:
- 研究双极性障碍中扫描器内脑活动与扫描器外认知评估之间的相关性.
- 在BD中弥合神经功能和认知表现之间的差距.
主要方法:
- 在BD中对fMRI研究的记忆/注意力进行系统的文献搜索.
- 包括在扫描仪内和扫描仪外进行认知评估的研究.
- 对各种临床状态 (缓解,症状) 的认知状态的分析.
主要成果:
- 工作记忆 (WM) 减少与下额 (IFG) 和腹侧前额皮层 (vlPFC) 激活的减少相关.
- 较差的执行功能和情节性记忆与中间前额叶皮层失活有关.
- 后壁皮层 (PPC),背侧PFC (dlPFC) 和IFG中较高的激活与更好的WM和执行功能相关.
结论:
- 前额外,时间和默认模式网络的改变激活与BD的认知表现较差有关.
- 基于任务的fMRI签名可能反映了BD中的真实世界认知功能.
- 需要进行纵向,经过良好控制的研究,以澄清神经激活模式的临床相关性.
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