儿童心脏病学中的左心房菌株:迄今为止的证据和未来的方向
Aparna Panatpur1, Donnchadh Martin O'Sullivan2, Candice Vacher3
1Department of Pediatrics, Baylor College of Medicine, Houston, TX.
概括
左心房应变 (LAS) 是儿童早期心脏功能障碍的关键指标. 研究表明,LAS在儿科心脏病中减少了,这将其与较差的结果联系起来,并指导未来的临床使用.
科学领域:
- 心脏病学 心脏病学
- 儿科心脏回声学 儿科心脏回声学
- 心脏生理学 心脏生理学
背景情况:
- 左心房应变 (LAS) 是早期心房和左心室扩张功能障碍的敏感标志物.
- 尽管LAS具有诊断潜力,但其在儿科心脏病学中的临床整合是有限的.
- 现有研究涵盖了2015年至2024年的57项研究,涉及超过5300名21岁以下的患者.
研究的目的:
- 审查和综合目前关于LAS在儿科心脏病中的作用的证据.
- 突出LAS与各种儿科心脏病的不良结果之间的关联.
- 确定对 LAS 临床实施的挑战和未来方向.
主要方法:
- 57项研究的系统审查和证据综合.
- 在健康的儿科,新生儿和成年人中分析LAS值.
- LAS参数 (LASr,LAScd) 与临床结果和疾病严重程度的相关性.
主要成果:
- 与新生儿和成年人相比,健康的儿童表现出更高的LAS值,特别是导管应变 (LAScd).
- 减少储和导管应变 (LASr,LAScd) 在先天性心脏病中很普遍,并且与不良结果有关.
- LAS 损伤与心肌病症中的透静功能障碍相关,预测MIS-C中的心肌损伤,并评估糖尿病和化疗诱导的心脏毒性风险.
结论:
- 左心房应变是一种有价值的,非侵入性的工具,用于评估儿科心脏功能和预测结果.
- 标准化LAS获取和分析协议对于广泛的临床采用至关重要.
- 需要进行进一步的前性研究,以确定儿童群体LAS的规范性数据和临床值.
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