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在怀孕期间和新生儿时使用抗生素B组链球菌病
Thi Cam Tu Ha1, Sheila Orwa1, Sandra Guedes2
1Department of Women's and Children's Health, Karolinska Institutet, 171 77 Solna, Sweden; Global Health Institute, Department of Family Medicine and Population Health, University of Antwerp, 2610 Antwerp, Belgium.
The Journal of infection
|December 31, 2025
概括
产前暴露于抗生素会增加新生儿在产后四周内患B组链球菌病 (GBS) 的风险. 这种风险在没有GBS风险因素的婴儿和在第三季度早期暴露期间更高.
科学领域:
- 产科和妇科 产科和妇科
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
背景情况:
- 乙组链球菌 (GBS) 是新生儿感染的重要原因.
- 产前抗生素的使用是常见的,但其对GBS疾病风险的影响尚未完全理解.
研究的目的:
- 调查产前抗生素暴露与新生儿生命前四周内GBS疾病发病率之间的关联.
主要方法:
- 在瑞典 (2006-2016) 开展的一项基于人口的队列研究分析了国家登记册数据.
- 单独活产的婴儿被按产前抗生素暴露分类.
- 在产后四周内确定了GBS疾病.
- 多变量逻辑回归估计调整的赔率比率 (aORs).
主要成果:
- 在1,095,644名新生儿中,有24.5%的新生儿在产前接触过抗生素.
- 暴露的新生儿 (0.86/1000) 与未暴露的新生儿 (0.66/1000) 的GBS发病率较高,aOR为1.29.
- 这种关联在没有GBS风险因素的新生儿中 (aOR, 1.34) 和在第三季度早期暴露的新生儿中 (aOR, 1.67) 较强.
结论:
- 产前抗生素暴露与早期出现GBS疾病的风险增加有关.
- 没有GBS风险因素的新生儿和在第三季度早期暴露的新生儿特别容易受到影响.
- 研究结果强调,需要考虑与GBS风险相关的产前抗生素使用的时间和指示.
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