非HACEK 格拉姆阴性细菌内心炎的患病率和危险因素;一个回顾性分析
Jason H Park1, Edwin Chen2, Divyia E Joseph2
1Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
The Canadian journal of cardiology
|December 31, 2025
概括
传染性内心炎 (IE) 在Serratia marcescens和Pseudomonas aeruginosa bacteremia中比Enterobacteriaceae更常见. 在有注射药物使用史和假体门的患者中,风险最高.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 感染性内心炎 (IE) 来自非HACEK 基因组阴性细菌 (GNB) 提出了诊断挑战和高死亡率.
- 了解国内生产总值中IE流行率变化对于风险分层至关重要.
研究的目的:
- 为了描述特定GNB细菌病患者的IE患病率.
- 为了确定与GNB相关的风险因素.
- 评估高风险患者的诊断性心声回声学实践.
主要方法:
- 从2018年至2022年对患有GNB细菌病 (Enterobacter cloacae,大肠杆菌,Klebsiella spp.,Pseudomonas aeruginosa,Serratia marcescens) 的成年患者进行了回顾性队列研究.
- 对临床数据,IE风险因素和IE诊断进行图表审查.
- 基于GNB物种和患者特征的IE患病率分析.
主要成果:
- 1.2% (82/6678) 的GNB细菌病患者发生IE.
- 塞拉蒂亚马尔塞森斯和Pseudomonas aeruginosa bacteremia显示IE患病率高于Enterobacteriaceae. 这两种细菌的患病率都比IE更高.
- 注射药物使用 (IDU) 和假显著增加了IE风险 (分别为43.1%和19.5%).
结论:
- 塞拉蒂亚马尔塞森斯和Pseudomonas aeruginosa与较高的IE患病率相关,而不是Enterobacteriaceae.
- 患有IDU和假发门病史的患者面临的风险最大.
- 临床实践显示,高风险GNBIE患者的诊断心声回声学使用的变化.
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