早期BPS诱导的甲状腺功能障碍对成年女性生殖障碍的影响
Lina Chouchene1, Mariem Ben Rhouma1, Sana Boughammoura1
1Laboratory of Genetics, Biodiversity and Bio-resources Valorization, Higher Institute of Biotechnology of Monastir, University of Monastir, Tunisia.
Chemico-biological interactions
|December 31, 2025
概括
产前暴露于双S (BPS) 破坏了母亲的甲状腺功能,导致雌性后代的长期生殖问题. 这种内分泌干扰剂会影响卵巢发育和激素平衡,影响生育能力.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
背景情况:
- 生殖障碍是一个日益严重的公共卫生问题.
- 早期的环境暴露是长期生殖结果的关键决定因素.
- 双S (BPS) 是一种新兴的内分泌干扰物,有可能干扰激素信号传递.
研究的目的:
- 调查产前双S (BPS) 暴露是否会影响成年雌性大鼠的生殖结果.
- 为了确定母体甲状腺功能障碍是否介导BPS对生殖健康的影响.
- 为了比较BPS与甲状腺激素受体 (THR) 抗剂的影响.
主要方法:
- 孕妇大鼠被暴露在BPS或THR抗剂 (AT 1-850) 中.
- 评估的参数包括体重,卵巢功能 (青春期,雌性周期,组织学,激素水平),氧化状态和卵细胞基因表达.
- 对青春期开始,雌性循环,卵泡发育,卵细胞发育和激素水平的评估影响 (E2).
主要成果:
- 产前BPS暴露导致早期青春期发作和不规则的雌性周期.
- 观察到毛囊发育受损,并积累了早期的毛囊.
- 卵细胞发育发生变化,由FIGLα和H1FOO基因表达的变化证明,并降低了E2水平.
- 效果与THR抗剂的效果相似,表明通过母体甲状腺干扰的共同机制.
结论:
- 在关键发育阶段,由BPS引起的母体甲状腺干扰会导致卵巢功能和结构的长期变化.
- 早期的BPS暴露会影响成年后女性的生殖功能和效率.
- 研究结果强调BPS是一种显著的内分泌干扰物,通过干扰甲状腺通路影响女性生殖健康.
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