动态酸乙交叉连接的氨酸水凝贴片,可快速溶解和快速口服粘膜输送无形苏马特里普坦
Zhuohao Gu1, Jiafeng Wang1, Xinglei Shi1
1College of Materials Science and Engineering, Nanjing Tech University, Nanjing, 211816, PR China; Sino-Spain Joint Laboratory on Biomedical Materials (S2LBM), Research Institute for Biomaterials, Tech Institute for Advanced Materials, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, NJTech-BARTY Joint Research Center for Innovative Medical Technology, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, PR China.
这项研究引入了适应pH值的氨酸-乙烯酸水凝膜,用于快速溶解的粘膜粘合口服药物输送. 这种新型系统有效地通过粘膜传递苏马特利普坦,提高生物可用性,并提供一种患者友好的选择.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 口服粘膜药物递送面临着粘膜凝固和快速溶解的挑战.
- 开发有效的膜系统用于像苏马特利普坦这样的药物是临床上具有意义的.
研究的目的:
- 开发一种适应pH值,粘粘性和快速溶解的水凝膜,用于口服粘膜药物输送.
- 通过开发的HA-PBA水凝膜来评估sumatriptan的通过粘膜传递.
主要方法:
- 通过EDC/NHS化合成酸修饰的酸 (HA-PBA).
- 使用NMR,FT-IR,UV-vis,DSC,XRD和SEM进行HA-PBA和含药膜 (BHA-SP) 的表征.
- 评估粘粘度,机械强度,分解,药物释放,体外透和体内药理动力学.
主要成果:
- HA-PBA水凝膜表现出pH依赖的自我交叉连接,优异的粘膜粘合和可调节的机械性能.
- 药物载入的膜显示在模拟的唾液中均的无形药物分散和快速分解 (<5秒).
- 活体研究表明持续的,接近零级的透,而在子体内以舌下给予子,与口服相比,导致快速吸收和增强的生物利用性.
结论:
- 开发的HA-PBA水凝膜是快速,有效和患者友好的口服粘膜药物递送的有希望的平台.
- 该系统表现出良好的生物相容性和治疗疗效,用于口腔的愈合.
- 这种响应pH的水凝为苏马特利普坦提供了一种高效的膜传递策略.
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