来自Atractylodes macrocephala的一种新型果糖可以通过肠道微生物介导的PI3K/Akt信号传递来改善性结肠炎
Jiangping Wu1, Qiangbao Xu1, Yiping Yang1
1Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu, 241002, China.
一种来自Atractylodes macrocephala Koidz. 的多糖. (AMP) 通过改善肠道屏障功能和微生物群平衡,有效治疗性结肠炎 (UC). 它的抗炎作用与PI3K/Akt通路有关,突出显示了它的治疗潜力.
科学领域:
- * 药理学和天然产品化学
- *胃肠道学和微生物学
背景情况:
- *食用植物和药用植物中的多糖具有改善肠道健康的潜力.
- * 性结肠炎 (UC) 是一种慢性炎症疾病,需要新的治疗策略.
研究的目的:
- * 为了隔离和表征一个多糖体 (AMP) 来自Atractylodes macrocephala Koidz.
- * 评估AMP在DSS诱导的性结肠炎小鼠模型中的疗效.
- * 阐明AMP对UC治疗效果的潜在机制.
主要方法:
- * 用生化方法分离和对AMP进行结构性表征.
- * 在DSS诱导的UC小鼠模型中对AMP疗效的体内评估.
- * 涉及便微生物种移植 (FMT),抗生素干预 (Abx),奥林克蛋白质组学和西部涂抹的机制研究.
主要成果:
- *AMP主要由果糖和葡萄糖组成,在小鼠中显著改善了UC症状.
- *AMP治疗改善了疾病活动指数,结肠长度,体重和杯细胞计数.
- *AMP恢复了肠道屏障的完整性,调节了肠道微生物群的稳定性,并调节了PI3K/Akt通路.
结论:
- *AMP在性结肠炎中显示出显著的治疗潜力.
- *AMP的有效性取决于维持肠道微生物群的恒温.
- *AMP代表了一种有前途的功能性食品成分或UC的天然治疗方法.
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