一种基于酸合的德克斯水凝的pH响应性药物递送系统,用于通过动态酸 Ester 键释放 doxorubicin
Yuqi Lu1, Longyu Deng1, Chunfeng Yin1
1Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.
Carbohydrate polymers
|December 31, 2025
概括
这项研究开发了一种pH响应的基于德克斯的水凝,使用酸 Ester 键进行向药物递送. 智能水凝在酸性瘤环境中证明了多克索鲁比辛 (DOX) 的受控释放.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 对刺激有反应的药物载体对于向治疗至关重要.
- 酸盐提供动态的共价键,可控制释放.
- 基于德克斯的水凝是药物输送的有希望的生物材料.
研究的目的:
- 开发一种智能,pH值敏感的基于德克斯的水凝,用于向药物输送.
- 为了利用Hantzsch交叉连接和酸盐结合用于凝制造.
- 在模拟瘤微环境中评估水凝的特性和药物释放特征.
主要方法:
- 使用汉茨奇反应和4-甲基酸 (FPBA) 制造双网络水凝 (DHPD-FPBA).
- 描述水凝结构,胀,机械性能和pH依赖的行为.
- 在不同pH值下对多克索鲁比辛 (DOX) 的加载和体外释放研究.
- 生物相容性评估和细胞吸收研究.
主要成果:
- 在pH 5.0下成功合成了DHPD-FPBA水凝,具有可调节的交叉链接和pH响应的分解.
- 通过酸盐结合,有效地加载DOX.
- 持续的和响应pH的DOX释放,pH值为5.0的释放率>65%,pH值为7.4的释放率<25%在48小时内.
- 佩帕斯模型表明了扩散-侵蚀合释放机制.
- 释放的DOX.高生物相容性和高效的细胞内化.
结论:
- DHPD-FPBA水凝表现出显著的pH响应性行为和受控的药物释放.
- 这种智能水凝平台显示出瘤微环境向药物输送的潜力.
- 双网络架构和酸盐链接使得治疗剂的释放能够精确.
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