系统性红斑狼的疾病持续时间和并发症负担之间的关联:来自巴基斯坦的多中心研究
Arsalan Tariq1, Maarij Sharif2, Muhammad Ammar2
1University Institute of Physical Therapy, The University of Lahore, Lahore, Pakistan at81931@gmail.com.
Lupus science & medicine
|December 31, 2025
概括
心血管疾病,慢性病和骨质疏松症等并发症在全身性红斑狼 (SLE) 患者中很常见,并且随着疾病持续时间的增加而增加. 早期,综合管理对于改善SLE患者的治疗结果至关重要.
科学领域:
- 风湿病学和免疫学
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,与显著的发病率有关.
- 心血管疾病 (CVD),慢性病 (CKD) 和骨质疏松症是已知的SLE并发症.
- 了解特定人群中这些并发症的患病率和预测因素对于有针对性的管理至关重要.
研究的目的:
- 为了确定在巴基斯坦旁遮普邦的SLE患者中CVD,CKD和骨质疏松症的患病率.
- 确定与这些并发症发展相关的预测因素.
- 检查SLE中疾病持续时间和并发症负担之间的关系.
主要方法:
- 进行了对未来的Punjab Lupus Registry (2020-2024) 的横截面分析.
- 分析了482名符合EULAR/ACR标准的成年SLE患者的数据.
- 多变量波桑回归确定了并发症负担的预测因素,疾病活性通过SLEDAI-2K进行评估.
主要成果:
- 43.6%的SLE患者至少有一种并发症,15.1%的患者有多种并发症.
- 随着疾病持续时间 (p<0.001),心血管疾病,CKD和骨质疏松症的患病率显著增加 (p<0.001).
- 独立预测因素包括年龄较大,疾病持续时间较长,皮质类固醇使用,吸烟和低社会经济地位;氧化具有保护作用.
结论:
- 在SLE患者中,并发症非常普遍,并且随着年龄和疾病持续时间的增加而升级.
- 这些发现凸显了积极查和综合管理战略的必要性.
- 早期干预和优化治疗可能会改善SLE患者的长期结果.
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