在病毒性脑炎的情况下,阿西克洛维尔诱导的毒性和神经毒性:一个病例报告
Bülent Dertli1, Sena Güzel Karahan2, Kadir Köseoğlu1
1Faculty of Pharmacy, Clinical Pharmacy, Inonu University, Malatya, Turkey.
European journal of hospital pharmacy : science and practice
|December 31, 2025
概括
临床药剂师优化了对简单疹病毒 (HSV) 脑炎的阿西克洛维尔剂量,防止严重的脏和神经毒性. 调整剂量和输液速率改善了患者的治疗结果,突出了药剂师主导的抗病毒治疗管理护理.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 病毒性脑炎,特别是简单疹病毒 (HSV) 脑炎,是一种关键的中枢神经系统疾病.
- 克洛维尔是治疗HSV脑炎的主要抗病毒药物,但如果不适当地使用,会带来毒性和神经毒性风险.
- 患者安全需要仔细管理阿西克洛维尔剂量和输液参数.
研究的目的:
- 为了说明临床药剂师在治疗HSV脑炎的阿西克洛维尔治疗中的关键作用.
- 为了证明个性化剂量调整如何减轻阿西克洛维尔诱导的毒性.
- 为了突出一个患者的成功治疗HSV脑炎经历经验性阿西克洛维尔治疗的不良影响的患者.
主要方法:
- 一份病例报告显示,一名54岁的男性患者出现了暗示HSV脑炎的症状.
- 基于脑脊液分析开始的经验性静脉注射阿西克洛维尔治疗.
- 临床药剂师干预调整阿西克洛维尔剂量并根据估计的淋巴细胞过率 (eGFR) 延长输液时间.
主要成果:
- 患者在阿西克洛维尔治疗的第三天出现了急性功能障碍,幻觉和精神运动动荡.
- 在调整了阿西克洛维尔剂量和输液持续时间后,患者的功能和神经状况显著改善.
- 通过修改的阿西克洛维尔治疗方案,成功地实现了治疗解决.
结论:
- 临床药剂师在优化抗病毒疗法,如阿西克洛维尔,用于中枢神经系统感染中发挥着至关重要的作用.
- 个性化剂量和长时间输液策略在尽量减少与阿西克洛维尔相关的毒性和神经毒性方面是有效的.
- 这一案例强调了合作药物治疗管理对HSV脑炎等危险感染的重要性.
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