在T细胞淋巴瘤中,与温克里斯治疗相关的急性视力丧失
Akash Paruthi1, Swati Srivastava2, Sunil Kumar Mahavar2
1Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India akashparuthi98@gmail.com.
BMJ case reports
|December 31, 2025
概括
温克里斯化疗很少会导致视神经病变,导致视力丧失. 用甲基prednisolone和pyridoxine迅速治疗导致T细胞淋巴细胞淋巴瘤患者显著的视觉恢复.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 眼科医生 眼科 眼科
背景情况:
- 文克里斯是治疗各种癌症的关键化疗剂.
- 视神经病变是一种罕见但严重的温克里斯的副作用,可能导致视力丧失.
研究的目的:
- 报告T细胞淋巴细胞淋巴瘤患者的温克里斯诱导的视神经病变病例.
- 强调早期诊断和干预这种并发症的重要性.
主要方法:
- 一名患有T细胞淋巴细胞淋巴瘤的患者在温克里斯化疗后出现了急性双侧视力损伤.
- 诊断工作排除了视力损失的其他原因.
- 治疗涉及高剂量静脉注射甲基prednisolone和pyridoxine补充剂.
主要成果:
- 患者在治疗后经历了快速和明显的视觉恢复.
- 温克里斯诱导的视神经病变被证实为诊断.
- 结果表明,在及时干预的情况下,这种情况具有可逆性.
结论:
- 温克里斯诱导的视神经病变是化疗的一个未被认可的并发症.
- 早期识别和及时治疗对于预防不可逆转的视力损伤至关重要.
- 这一案例凸显了在温克里斯治疗期间对视觉副作用的警的必要性.
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