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在患有短肠综合征的儿科患者中,有症状的维生素A缺乏
Tatsuya Takahashi1, Itaru Hayakawa2, Tetsuya Ishimaru3
1Division of Neurology, National Center for Child Health and Development, Setagaya, Japan takahashi-ta@ncchd.go.jp.
BMJ case reports
|December 31, 2025
概括
维生素A缺乏症会导致短肠综合征 (SBS) 的儿童患有异眼症,即使是通过肠道营养. 迅速的肌肉内维生素A治疗有效地解决了这些严重的眼部症状.
科学领域:
- 眼科医生 眼科 眼科
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
背景情况:
- 维生素A缺乏导致异眼症,在发达国家并不常见.
- 吸收不良状况,如短肠综合症 (SBS),可以导致维生素A缺乏.
- 短肠综合征 (SBS) 通常需要长期的肠外营养支持.
研究的目的:
- 在患有SBS的儿科患者中报告症状性异眼症的病例.
- 为了突出维生素A缺乏的潜力,尽管亲肠道营养.
- 强调定期眼科查和及时诊断的重要性.
主要方法:
- 一个早期青少年男性的病例介绍,他患有与低腺结相关的SBS.
- 临床评估包括夜间失明,结膜异质症和比托斑.
- 血清雷丁醇水平和肌肉内维生素A的生化评估.
主要成果:
- 这位患者出现了严重的维生素A缺乏 (血清二甲醇4.2μg/dL).
- 观察到眼部表现,包括夜间失明和光化症.
- 肌肉内高剂量维生素A导致症状完全消失.
结论:
- 患有SBS的儿科患者有患有症状的异眼症的风险,不管营养支持如何.
- 定期的眼科检查对于早期发现眼部异常至关重要.
- 肌肉内维生素A是一种有效的治疗干预,用于维生素A缺乏的二次性吸收不良.
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