炎症性肠病患者的饮食和临床缓解:一个多中心的横截面研究
Lucile Fontaine1, Philippe Seksik2, Carmen Stefanescu3
1Université Paris-Saclay, UVSQ, Inserm, Gustave Roussy, CESP, 94805, Villejuif, France; Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France.
饮食习惯会影响炎症性肠病 (IBD) 的活动. 对于克罗恩病 (CD) 缓解,水果,咖啡和地中海饮食是有益的. 对于性结肠炎 (UC) 缓解,水果和沙拉显示出积极的关联.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 饮食因素越来越多地被认为在炎症性肠病 (IBD) 病原和进展中的作用.
- 以前的研究已经广泛探讨了饮食和IBD发展风险之间的联系,但与疾病活动的关联需要进一步调查.
研究的目的:
- 研究特定饮食成分与IBD患者的临床缓解之间的关联.
- 为了区分饮食对克罗恩病 (CD) 和性结肠炎 (UC) 活动的影响.
主要方法:
- 一项涉及2514名门诊患者 (1715名CD患者,799名UC患者) 的横截面研究,涉及法国和比利时的40个中心.
- 评估饮食摄入量和IBD活动使用2023年4月至5月期间的问卷.
- 经过对潜在混因素进行调整的统计分析,包括性别,年龄,BMI,教育,吸烟状况和之前的CD手术.
主要成果:
- 在CD患者中,临床缓解与较高的水果摄入量 (aOR 1.60) 和咖啡 (aOR 1.57) 有显著的关联.
- 在UC患者的临床缓解与增加的水果 (aOR 1.72) 和沙拉 (aOR 1.73) 消费有关联.
- 坚持地中海饮食与CD缓解有关 (aOR1.39),但与UC缓解无关. 一般来说",健康饮食"与CD或UC的缓解没有显著的关联.
结论:
- 特定的饮食成分,包括水果,咖啡和坚持地中海饮食,与克罗恩病的改善临床缓解有关.
- 对于性结肠炎,更多的水果和沙拉消费与临床缓解有关.
- 横截面设计限制了最终的因果结论,强调了逆因果关系的可能性作为一个限制.
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