视网母细胞瘤的静脉内化疗后严重的视力损失和眼部并发症
Carlos Solera-de-Andrés1, Paula Spang-Valencia2, Jesús Peralta-Calvo2
1Ophthalmology, Hospital Universitario La Paz, Madrid, Community of Madrid, Spain soleradeandres.c@gmail.com.
The British journal of ophthalmology
|December 31, 2025
概括
动脉内化疗 (IAC) 保护了视网膜母细胞瘤 (RB) 的眼睛,但往往导致视力低下. 叶干涉和诸如冠状闭塞性血管病变等并发症显著影响最终的视力敏度 (VA).
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 医疗成像医学成像
背景情况:
- 视网母细胞瘤 (RB) 治疗优先考虑生存,地球保存和视觉功能.
- 动脉内化疗 (IAC) 改善了RB的全球救援率.
- 有限的数据存在于RB的IAC治疗后的视觉结果.
研究的目的:
- 在接受动脉内化疗 (IAC) 的视网膜母细胞瘤 (RB) 患者中评估最终视力敏度 (VA).
- 为了确定导致RB患者接受IAC视力损失的因素.
- 作为次要结局,评估胆道封闭性血管病变 (COV) 的发生率.
主要方法:
- 从60名用IAC治疗的RB患者71只眼睛的回顾性审查 (2016-2025年).
- 数据包括国际视网母细胞瘤分类和叶参与.
- 视力敏度 (VA) 通过斯内伦图表评估,转换为logMAR;记录了COV发病率.
主要成果:
- 在27只具有可测量的VA的眼睛中,23只 (85.2%) 的VA≥1.0 logMAR (10只没有光感知).
- 只有4只眼睛 (14.8%) 达到VA<1.0 logMAR,所有眼睛在诊断时都具有健康的眼.
- 诊断时的状卷入与减少的最终VA显著相关;22.5%的患者发展了COV,与IAC周期号相关.
结论:
- IAC对于视网膜母细胞瘤瘤控制和眼睛保护是有效的.
- 视力不佳的结果在先进的RB中很常见,这是由于先前存在的损伤和COV等并发症.
- 必须向家庭提供与IAC治疗相关的潜在视力限制的咨询.
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