成年人脑的连接性与循环和转录学签名的顺序神经发生
Ibai Diez1,2,3,4, Fernando García-Moreno4,5,6, Nayara Carral-Sainz7
1Center for Inflammation Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nature communications
|December 31, 2025
概括
人类大脑网络遵循"变老变富"的规则,早期发达的区域成为关键枢纽. 基于相似的发育时间形成的连接,影响大脑结构和功能.
科学领域:
- 系统神经科学 系统神经科学
- 神经发育生物学 神经发育生物学
- 计算神经科学是一种计算神经科学.
背景情况:
- 了解人类连接体的架构对于系统神经科学至关重要.
- 大脑区域的发育时间表可能会影响网络组织.
研究的目的:
- 研究大脑区域的胚胎年龄与它们在人类连接体中的中心地位之间的关系.
- 探索发育时间如何影响结构性和功能性大脑连接.
主要方法:
- 利用基于胚胎年龄的人类大脑细分.
- 分析了大脑节点的结构和功能中心性.
- 进行了大脑转录组分析,以将基因表达与发育时间和网络特性相关联.
主要成果:
- 节点的结构中心性与它们的胚胎年龄正相关 (年龄越大越丰富的规则).
- 功能中心性显示了相反的趋势.
- 节点之间的胚胎年龄差异与链接概率和重量相反相关.
- 胚胎年龄与与神经系统发育和神经疾病相关的基因表达有关.
结论:
- 人类大脑的布线遵循结构枢纽的"变老变富"原则.
- 一个基于神经生成时间的偏好依恋规则塑造了大脑的连接.
- 发育时间显著影响人类连接组中的结构-功能关系.
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