在乳腺癌中调节NF-κB的MiRNA的双面作用
Mukesh Kumar Manickasamy1, Ravichandran Vishwa1, Anjana Sajeev1
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, 781039, India.
Cancer cell international
|December 31, 2025
概括
微RNAs (miRNAs) 调节激活B细胞 (NF-κB) 在乳腺癌 (BC) 中发出信号的核因子卡帕-光链增强器. 本综述探讨了miRNA在BC中的作用,重点关注针对NF-κB通路的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因规则 基因规则
背景情况:
- 乳腺癌 (BC) 是女性癌症死亡的主要原因.
- 激活B细胞 (NF-κB) 信号传导的异常核因子卡帕光链增强剂驱动BC进展,转移和治疗抵抗.
- 微RNAs (miRNAs) 是关键的转录后调节者,影响BC的代和治疗结果.
研究的目的:
- 为了审查miRNAs和NF-κB信号传递在乳腺癌中的复杂相互作用.
- 概述了用于BC治疗的miRNA传递技术的临床前进展.
- 讨论基于miRNA的治疗方法对个性化BC管理的临床影响.
主要方法:
- 在BC研究miRNA-NF-κB相互作用的研究的文献综述.
- 分析miRNA作为瘤抑制剂或瘤调节剂的作用.
- 检查临床前miRNA输送系统和临床试验数据.
主要成果:
- miRNAs在调节NF-κB信号传递方面表现出上下文依赖的作用,作为瘤抑制剂或瘤基因.
- 通过瘤抑制器miRNAs (TS-miRs) 或抑制瘤性miRNAs (OncomiRs) 准NF-κB信号提供治疗潜力.
- 在miRNA传递技术的进步正在为新的BC治疗铺平道路.
结论:
- miRNAs作为乳腺癌的治疗剂具有显著的翻译潜力.
- miRNAs可以作为个性化BC管理策略的预测生物标志物.
- 调节miRNA-NF-κB相互作用是克服BC疗法耐药性的有希望的途径.
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