当算法推断性别时:重新审视计算表型化与电子健康记录数据的数据
Jessica Gronsbell1, Hilary Thurston2, Lillian Dong3
1Department of Statistical Sciences, University of Toronto, Toronto, M5G 1X6, ON, Canada. j.gronsbell@utoronto.ca.
Biology of sex differences
|December 31, 2025
概括
计算表型化使用算法从电子健康记录 (EHR) 中推断性别,改善代表性不足的群体的数据. 然而,这种方法在潜在的滥用方面引发了重大的伦理和方法问题.
科学领域:
- 生物医学信息学 生物医学信息学
- 医疗信息学 医疗信息学
- 计算流行病学计算流行病学
背景情况:
- 电子健康记录 (EHR) 往往缺乏全面的性别数据,阻碍了对特定人群的研究.
- 计算表型化提供了一种方法,可以使用现有的EHR数据推断性别.
- 这种方法旨在加强跨性别和性别扩展型个人的纳入研究.
研究的目的:
- 在EHR中对性别计算表型进行叙事审查.
- 批判性地检查与这种方法相关的方法和道德挑战.
- 提出未来的研究重点,并强调现有的建议.
主要方法:
- 叙事文学评论. 叙事文学评论. 叙事文学评论. 叙事文学评论.
- 对用于性别推断的计算表型化方法学的批判性分析.
- 检查对算法输出的伦理影响和潜在滥用.
主要成果:
- 计算表型化可以解决关于性别的电子健康记录中的数据缺口.
- 在算法开发和验证方面存在重大方法挑战.
- 伦理方面的担忧包括潜在的错误性别和误用推断数据的可能性.
结论:
- 计算表型是一个有价值的工具,但需要仔细实施.
- 解决伦理和方法方面的问题对于负责任的使用至关重要.
- 需要进一步的研究,以确保生物医学研究中的公平和准确应用.
相关概念视频
The Ratio of X Chromosome to Autosomes
9.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
9.4K
The Y Chromosome Determines Maleness
7.8K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
7.8K
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Pedigree Analysis
88.7K
Overview
88.7K


