可注射类疗法:骨科和体育医学医生的一本入门书
Cory K Mayfield1, Ioanna K Bolia1, Cailan L Feingold1
1Keck School of Medicine of USC, Los Angeles, California, USA.
The American journal of sports medicine
|January 1, 2026
概括
可注射类疗法显示出组织修复和体育表现的潜力,但目前的证据有限. 需要更多的研究来证实这些流行的治疗方法对骨科疾病的安全性和有效性.
科学领域:
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
- 运动医学 运动医学
背景情况:
- 治疗性,短链氨基酸,调节细胞功能,在骨科创伤中越来越受欢迎.
- 随着市场的不断增长和患者的兴趣,骨科外科医生需要了解这些治疗背后的证据.
研究的目的:
- 评估可注射疗法在再生医学和体育表现方面的证据和应用.
- 帮助骨科提供者了解当前的治疗方法.
主要方法:
- 进行了对文献的叙事审查.
- 在PubMed中搜索了对流行的注射性的生物化学和临床研究,包括BPC-157,TB-4,TB-500,CJC-1295 + ipamorelin,tesamorelin和GHK-Cu.
主要成果:
- BPC-157显示了肌/肌肉修复的潜力,但缺乏可靠的人类数据. 结核病-4/TB-500在临床前模型中显示出希望,但缺乏骨科证据,并且在体育赛事中被禁止使用.
- 在动物模型中,CJC-1295 + ipamorelin 改善了肌肉力量. 特萨莫雷林没有骨科证据,GHK-Cu缺乏肌肉骨疾病的临床数据.
结论:
- 类治疗有潜力,但目前缺乏临床骨科使用的证据.
- 指示,剂量和安全性在很大程度上是未知的,在提出建议之前需要进一步的研究.
- 骨科和体育医学提供者必须了解尽管患者受欢迎,但证据有限.
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