病例报告:乳腺的复发性乳腺瘤与渐进的恶性转变
Chuanyan Wang1, Shangui Wang1, Jiao Wang2
1Department of Oncology, Rizhao People's Hospital, Rizhao, China.
Frontiers in oncology
|January 1, 2026
概括
乳腺的Phyllodes瘤 (PTB) 可以从良性发展为恶性,如在患有复发性PTB的患者中所见. 像Ki-67,MDM2和p53这样的分子标记可能表明恶性转变.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 手术瘤学手术瘤学
背景情况:
- 乳腺瘤 (PTB) 是一种罕见的纤维皮质瘤.
- PTB经常被误诊为纤维腺瘤,可能会推迟适当的治疗.
- 虽然通常是良性的,但一些PTB表现出恶性潜力,包括复发和转移.
研究的目的:
- 呈现一个患有恶性进展的乳腺瘤 (PTB) 的病例.
- 要突出与PTB转化相关的潜在分子标记.
- 讨论复发性和恶性PTB的治疗策略.
主要方法:
- 一个52岁的女性患者的病例报告,她有复发性PTB的病史.
- 组织病理学分析包括免疫组织化学 (Ki-67,MDM2,p53).
- 用修改的激进乳房切除术和全身化疗 (伊福斯法米德和西斯) 进行治疗.
主要成果:
- 患者的PTB从良性发展到边缘性,恶性,多次复发的骨髓瘤分化.
- 免疫组织化学显示Ki-67 (8%到70%),MDM2阳性和p53表达异常的增加.
- 在治疗后,患者在36个月后仍然没有疾病,没有复发或转移.
结论:
- 乳腺的乳腺瘤可以表现出恶性转变和进展.
- 基-67指数升高和MDM2/p53的变化可以作为恶性变化的指标.
- 个性化治疗,可能参考软组织肉瘤协议,对于管理积极的PTB至关重要.
相关概念视频
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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