可编程相位过渡使得可调节的微结构和微力学能够在热敏多糖水凝中实现
Saniya Yesmin Bubli1, Rabeya Sharmin Lima1, Katherine Salvatore1
1Department of Chemical Engineering and Bioengineering, University of New Hampshire, Durham, NH USA.
概括
这项研究引入了可编程的基于德克斯的水凝,具有可调节的热响应相位过渡. 表面活性剂的特性决定了先进生物复合材料设计的微观结构和机械特性.
科学领域:
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
背景情况:
- 聚合物-表面活性剂相互作用对于设计具有特定性质的功能材料至关重要.
- 控制聚合物聚合和相变是材料设计的关键.
研究的目的:
- 开发可编程的基于德克斯的热敏多糖缩物.
- 研究不同表面活性剂如何影响相位过渡动态和水凝微观结构.
- 为了确定表面活性剂修改的多糖水凝中的结构性质关系.
主要方法:
- 合成基于德克斯的热敏多糖缩物.
- 利用光启动的基质聚合用于水凝交叉连接.
- 系统地研究了阳离子 (SDS),阴离子 (CTAB),非阳离子 (Pluronic F-127) 和离子 (CHAPS) 表面活性剂的作用.
- 完成了由此产生的水凝的微机械表征.
主要成果:
- 在多糖缩物中达到可调节的较低的临界溶液温度.
- 经过表现的表面活性剂特定的水凝微结构 (核心外,延长的粒,双重乳液).
- 观察到结构依赖的机械性能,包括刚性和粘附性.
- 发现表面活性剂的电荷密度,HLB和CMC共同控制相位分离.
结论:
- 开发了一个设计基于多糖的水凝的框架,具有量身定制的微观结构和机械性能.
- 展示了通过受控的聚合物-表面活性剂相互作用来指导材料特性的能力.
- 突出了创建具有可调节性能的先进生物复合材料的潜力.
更多相关视频
12:22Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
Published on: March 1, 2016
8.7K
12:07Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
Published on: April 16, 2018
13.9K
相关概念视频
Cooperative Allosteric Transitions
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Mechanisms of Membrane-bending
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
Cooperative Allosteric Transitions
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cell-matrix's Response to Mechanical Forces
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
