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HCCS作为人类乳腺癌的潜在预后生物标志物和治疗目标

Sm Faysal Bellah^1,2, Md Alim Hossen³, S M Saker Billah⁴

¹Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh, bu.edu.bd.

International journal of breast cancer

|January 1, 2026

概括

全细胞染色体c合成酶 (HCCS) 在乳腺癌中过度表达,特别是三阴性乳腺癌 (TNBC). 高HCCS表达表明预后较差,免疫细胞透率增加,这表明它是潜在的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

乳腺癌是全球主要的健康问题,三阴性乳腺癌 (TNBC) 存在重大治疗挑战.
全细胞染色体c合成酶 (HCCS) 是一种线粒体酶,与癌症的发展有关.
了解HCCS的作用对于推进乳腺癌治疗至关重要.

研究的目的:

综合分析HCCS在各种癌症中的表达,表观遗传调节,免疫相互作用和预后价值,重点关注乳腺癌亚型.
确定HCCS作为潜在的生物标志物和治疗点.

主要方法:

使用TCGA,UALCAN,TNMplot,Kaplan-Meier Plotter,TIMER2.0,STRING,以及g:Profiler进行综合生物信息学分析.
在多种癌症类型中分析了HCCS表达,甲基化,生存结果和免疫透.
在来自GEO和GOBO的独立乳腺癌队列中验证的结果.

主要成果:

在癌症中,HCCS显著上调,最显著的是乳腺癌和TNBC.
低甲基化HCCS促进体与增加的HCCS表达相关.
升高的HCCS表达与更糟糕的无复发存活率和免疫细胞 (例如CD4 +,CD8 + T细胞,巨细胞) 的透率增加有关.
与HCCS相关的基因在线粒体和亡途径中得到了丰富.

结论:

HCCS是一种潜在的预后生物标志物和乳腺癌,特别是TNBC的治疗点.
临床转换需要进一步的实验验证.

关键词:

在HCCS中,我们使用的是HCCS.和TCGA,以及TCGA.乳腺癌乳腺癌乳腺癌免疫透免疫透是什么?总体存活率总体存活率没有复发的生存率.

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