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在发生心血管疾病之前和之后的脆弱指数变化
Xiao-Yu Qian1, Cong-Di Wang1, Chun-Xiao Liu2
1Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Journal of geriatric cardiology : JGC
|January 1, 2026
概括
随着时间的推移,心血管疾病 (CVD) 和脆弱性相互加速. 这项研究表明,心血管疾病前后的脆弱性恶化,心血管疾病发病的脆弱性升,表明老龄化人口的双向关系.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 和虚弱是老年人群中常见的,相互关联的疾病.
- 心血管疾病和脆弱性之间的动态时间关系尚未得到充分理解.
- 这项研究检查了发生心血管疾病的时间周围的纵向脆弱性轨迹.
研究的目的:
- 调查心血管疾病 (CVD) 发病前和之后的脆弱性轨迹的纵向变化.
- 探索各种跨国队伍中脆弱性和心血管疾病之间的时间相互作用.
- 为将脆弱性评估纳入老年人心血管疾病管理策略提供见解.
主要方法:
- 利用了来自四个大型跨国纵向队列 (ELSA,HRS,CHARLS,SHARE;n=66,537) 的数据.
- 使用与年龄相关的健康缺陷 (每个队列40-44项) 构建了虚弱指数 (FI).
- 采用线性混合模型来评估CVD前后的FI变化,对共变量进行调整;进行敏感性分析.
主要成果:
- 在所有队列中,心血管疾病发病前的脆弱性始终增加 (心血管疾病前的斜率:β = 0.005-0.012,P < 0.001).
- 在心血管疾病诊断时观察到急性虚弱增加 (心血管疾病后急性变化:β = 0.024-0.046,P < 0.001).
- 在心血管疾病发作后,脆弱性进展显著加快 (心血管疾病后的斜率:β = 0.005-0.017,P < 0.001).
结论:
- 这项跨国研究揭示了心血管疾病发病时间附近的脆弱性双向加速.
- 这些发现凸显了心血管疾病和老年人的虚弱之间紧密的时间相互作用.
- 将脆弱性评估纳入心血管疾病护理可以识别有风险的个体并指导多维干预.
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