默认模式网络和视觉网络对通过皮肤进行的耳膜迷走神经刺激的响应性预测了其在原发性失眠障碍中的可变有效性
Xiao Wu1,2, Hua Duan2, Yishuang Wang3
1Post-Doctoral Research Station, Affiliated Sport Hospital of Chengdu Sport University, Chengdu, Sichuan, China.
Frontiers in neurology
|January 1, 2026
概括
通过皮肤进行的耳膜迷走神经刺激 (taVNS) 通过调节大脑网络和自主功能来改善原发性失眠障碍 (PID). 在默认模式和视觉网络中的基线大脑活动可以预测治疗成功.
科学领域:
- 神经科学是一个神经科学.
- 医学科学 医学科学 医学科学
背景情况:
- 通过皮肤进行的耳膜迷走神经刺激 (taVNS) 对初级失眠障碍 (PID) 有效.
- 对于PID的taVNS治疗疗效存在个体间的变化.
研究的目的:
- 在PID中研究可变taVNS疗效背后的大脑功能机制.
- 确定潜在的生物标志物来预测taVNS治疗结果.
主要方法:
- 随机对照试验,包括54名PID患者 (真实与虚假taVNS).
- 另外46名患者接受了真正的taVNS,用于增强生物标志物分析.
- 评估的大脑活动 (mALFF) 和自主神经系统 (ANS) 反应 (HRV).
主要成果:
- 在传感器,默认模式和视觉网络中,taVNS增加了mALFF.
- 基线DMN+VN mALFF与taVNS疗效相关.
- 心率变化 (HF) 在治疗后显著增加.
- 基线DMN/VN mALFF与taVNS期间的HF相关.
结论:
- taVNS可以通过调节DMN,VN和SMN活动来治疗PID,调节ANS.
- DMN+VN+SMN网络的功能响应与taVNS疗效的可变性相关.
- 基线DMN/VN活动和刺激期间的HF是taVNS有效性的潜在预测生物标志物.
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