相关实验视频
Updated: Jan 7, 2026

12:22
Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
9.9K
胺诺曼南相关蛋白2 (Pap2) 参与粘附和毒性
Dario A Baruch-Martínez1, Manuela Gómez-Gaviria1, Joaquín O Chávez-Santiago1
1Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, Gto, Mexico.
Infection and drug resistance
|January 1, 2026
概括
新发现的Sporothrix schenckii中的Pap2蛋白质有助于真菌粘附到宿主组织. 用Pap2接种疫苗可以保护运动三症,强调其作为治疗点的潜力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 病变的发生和发病.
- 免疫学 免疫学 免疫学
背景情况:
- *Sporothrix schenckii*的细胞壁对于病变发生至关重要.
- 之前的研究已经确定了细胞壁部件甲诺曼南 (PRM) 中未知的功能蛋白.
- 由SPSK_06559基因编码的蛋白质在PRM中非常丰富.
研究的目的:
- 研究SPSK_06559蛋白 (Pap2) 对细胞外基质 (ECM) 组件的粘合性.
- 通过实验验证Pap2的预测粘合性能.
- 通过使用Galleria mellonella*感染模型,评估Pap2在Sporothrix schenckii*发病过程中的作用.
主要方法:
- 在分析中预测Pap2对ECM组件 (纤维素,纤维菌素,原体) 的粘附.
- 用于实验验证的复合Pap2 (rPap2) 的生成.
- 评估Pap2在*Galleria mellonella*幼虫的发病过程中的作用.
主要成果:
- 生物信息学预测表明,Pap2具有粘合性.
- 实验验证证证实了rPap2对ECM组件的强粘附性.
- 使用rPap2的免疫接种为G. mellonella幼虫提供了对S. schenckii的显著保护.
- 用抗体阻断Pap2可以降低幼虫的真菌致死率.
结论:
- 在 *Sporothrix schenckii* 感染期间,Pap2 促进了对宿主组织的初始粘附.
- 帕普2是一种有前途的免疫原抗原,可用于开发针对运动三症的疫苗.
- 帕帕2在病变发生过程中起着至关重要的作用,是潜在的治疗点.
相关概念视频
Adherens Junctions
6.1K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
6.1K
Fimbriae, Pili, and Axial Filaments
1.4K
Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...
1.4K
Cell Adhesion in Plants
3.2K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.2K
Intracellular Signaling Affects Focal Adhesions
3.4K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
3.4K
Surface Appendages of Archaea
534
Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...
534
Types of Membrane Protrusions
3.5K
The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
The microvilli, an example of stable protrusions, are finger-like projections...
3.5K

