调查局部麻醉剂在完全植入的静脉接入器件上的非角针插入中有效的应用时间
Guowei Jiang1, Xiaolei Yang1, Liye Yang1
1Department of Anesthesiology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, People's Republic of China.
在完全植入式静脉接入装置 (TIVAD) 程序中,EMLA奶油和甲化凝提供有效的止痛药. 甲凝比EMLA奶油更快地获得有效的止痛效果,具有类似的安全性.
科学领域:
- 麻醉学 麻醉学
- 在瘤学瘤学.
- 血管接入 血管接入
背景情况:
- 在涉及完全植入式静脉接入装置 (TIVAD) 的手术中,疼痛管理至关重要.
- 局部麻醉剂通常用于减少与针头插入TIVADs相关的疼痛.
- 确定局部麻醉剂的最佳应用时间对于有效的止痛至关重要.
研究的目的:
- 为了比较EMLA奶油和甲化凝在在TIVAD中插入针头时提供止痛的疗效.
- 为了确定EMLA奶油和四氨酸化物凝的中位有效时间 (ET50) 和95%有效时间 (ET95).
- 评估与使用这些局部麻醉剂相关的安全性和不良反应.
主要方法:
- 一项随机研究比较EMLA奶油 (2g) 和甲化凝 (1g) 用于TIVAD手术.
- 局部麻醉剂应用于穿刺部位周围1厘米半径的区域.
- 应用时间根据先前参与者的疼痛评分 (数值评分表) 调整,使用1:1:1的时间梯度;用于确定ET50和ET95.5的探针分析.
主要成果:
- 在EMLA奶油中,ET50为55.9分钟,ET95为63.6分钟.
- 甲化凝实现了ET50的39.1分钟和ET95的43.4分钟.
- 两组之间轻度或严重的不良反应没有显著差异.
结论:
- 与TIVAD手术的EMLA奶油相比,甲化凝显示出有效止痛的更快开始.
- 64分钟使用EMLA奶油或44分钟使用四甲凝,可在95%的患者中确保无痛针刺.
- 在TIVAD接入期间,EMLA奶油和甲凝都是安全有效的止痛选择.
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