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扫除ROS的纳米材料作为骨组织再生的新兴工具:对最近进展的全面审查

Wanzhuo He^1,2,3, Tian Xu³, Miao Wang^2,4

¹Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Acta pharmaceutica Sinica. B

|January 1, 2026

概括

活性氧物种 (ROS) 对于骨再生至关重要. 吸收ROS的纳米材料可以通过平衡骨形成和再吸收来改善骨愈合,为骨缺陷提供了有希望的替代治疗方法.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

骨缺陷带来了重大的临床挑战,当前的治疗方法如自体移植和异体移植都有局限性.
过度的活性氧物种 (ROS) 破坏了骨再生平衡,阻碍了愈合.
抗氧化剂可以减轻氧化应激,恢复骨形成和再吸收之间的平衡.

研究的目的:

审查用于骨组织再生的ROS清理纳米材料.
探索它们的设计策略,机制,应用以及临床翻译潜力.

主要方法:

在骨再生中使用ROS-scavenging纳米材料的综合文献综述.
对纳米材料设计,ROS清理机制和治疗功效的分析.
对临床翻译前景的评估.

主要成果:

纳米技术使得开发用于骨再生的ROS清理纳米材料成为可能.
这些纳米材料作为抗氧化剂输送系统或直接ROS中和剂.
清除ROS的纳米材料通过恢复骨再生平衡来提高治疗效率.

结论:

清除ROS的纳米材料代表了对骨缺陷的有前途的治疗策略.
对其设计和临床应用的进一步研究是有必要的.
这些先进的材料有潜力克服当前骨移植技术的局限性.

关键词:

提供抗氧化剂的输送.骨缺陷骨缺陷骨缺陷骨缺陷骨再生骨的再生骨组织工程骨组织工程临床翻译临床翻译纳米平台的使用方法纳米酶是一种纳米酶.在ROS-scavenging纳米材料中使用.

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