基化Smilax glabra粉通过肠-皮肤轴调节通过结肠向的输送来缓解亚托邦性皮炎
Nan Wang1, Lingling Wu1, Yaya Su1
1Department of Pharmacy, Air Force Medical Center, PLA, Air Force Medical University, Beijing 100142, China.
Acta pharmaceutica Sinica. B
|January 1, 2026
概括
丁化Smilax glabra粉 (BSGS) 通过在结肠中释放丁酸盐,有效治疗亚托皮炎 (AD). 这种新的方法调节肠-皮肤轴,减少炎症并改善潜在的AD治疗的肠道健康.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 亚托邦性皮肤炎 (AD) 是一种广泛的炎症性皮肤疾病,具有免疫失调.
- 丁酸盐是一种来自肠道微生物群的短链脂肪酸,显示出对AD有益的抗炎性质.
- 针对阿尔茨海默病的治疗,向结肠注入酸的向治疗方法仍未得到充分研究.
研究的目的:
- 合成基化Smilax glabra粉 (BSGS) 用于结肠特异性酸盐释放.
- 通过调节肠-皮肤轴来研究BSGS对亚托皮炎 (AD) 的治疗疗效.
主要方法:
- BSGS的合成和特征是其晶体结构和抵抗消化的能力.
- 试管发酵评估了BSGS生产短链脂肪酸和影响微生物组成的能力.
- 用AD小鼠模型来评估BSGS对皮肤炎症,细胞因子水平,肠道屏障和肠道微生物群的影响.
主要成果:
- 在发酵过程中,BSGS对胃肠道消化表现出耐药性,并促进了酸盐的产生.
- 在AD小鼠中施用BSGS可降低皮肤炎症,降低血清前炎性细胞因子,并改善肠道屏障功能.
- BSGS调节了肠道微生物组成,并抑制了NF-κB炎症途径.
结论:
- BSGS作为一种针对结肠的新甲基酸盐供体,具有针对亚托皮炎的显著治疗潜力.
- 通过酸盐释放调节肠皮轴和免疫反应是BSGS疗效的关键机制.
- 通过准肠道微生物群和炎症,BSGS提供了一种有希望的AD管理策略.
相关概念视频
01:17Drugs for Treatment of Diarrhea-Predominant IBS
593
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
593
01:21Drugs for Treatment of Constipation-Predominant IBS
670
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
670
01:29Drugs for Treatment of Ulcerative Colitis in IBD
416
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
416
01:20Drugs Affecting GI Tract Motility: Other Laxatives
975
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
975
01:22Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
506
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
506
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K