系统性炎症反应综合征 (SIRS) - - 在输注不受管制的IV补充剂Hemobex后的类似反应
Jace A Leslie1, Michael Silberman1, Vasilios Katsaitis2
1Emergency Medicine, Ascension St. Thomas Rutherford/University of Tennessee Health Science Center Graduate Medical Program, Murfreesboro, USA.
Cureus
|January 1, 2026
概括
不规范的IV补充剂可以导致严重的全身炎症反应综合征 (SIRS) 类似反应模仿败血症. 临床医生必须在暴露于未经批准的输液的患者中怀疑这些有毒反应.
科学领域:
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 不受监管的补充剂,包括肠道配方,被广泛用于感知健康益处.
- 在没有医疗监督的情况下给予药物会给健康带来重大风险.
- 这些输液可以触发类似于全身炎症反应综合征 (SIRS) 的反应,模仿败血症.
研究的目的:
- 报告在未经调节的IV维生素制剂后出现SIRS类反应的情况.
- 为了突出模仿败血症的有毒或免疫反应的潜力.
- 强调需要临床警和监管监督.
主要方法:
- 一个以前健康的21岁男性的病例报告.
- 详细的临床表现和实验室发现.
- 综合性传染病和毒理学检查,包括成像和腰部穿刺.
- 通过支持性护理和经验性抗生素进行管理.
主要成果:
- 患者出现了发烧,心动减速,胃肠道症状,脑病变,白血病,白血细胞病,超氨基酶升高和乳酸性酸性.
- 传染病和毒理学工作是负面的.
- 临床和实验室异常通过支持性护理迅速消失.
结论:
- 呈现与细胞因子介导的SIRS类反应或培养负性败血症一致.
- 潜在的触发因素包括内毒素污染或从不受管制的输注中释放细胞因子.
- 临床医生应该考虑不受管制的IV补充剂是导致败血症的原因.
相关概念视频
Inflammatory Response I: Vascular and Cellular
15.8K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
15.8K
Allergic Drug Reactions
1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Hypersensitivities
6.9K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.9K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
7.2K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.2K
Inflammatory Response
15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
Allergic Reactions
31.9K
Overview
31.9K


