在黎巴嫩的血液透析患者中使用利尿剂:一项多中心观测回顾性研究
Iqbal Fahs1,2, Faten Ezzeddine1, Mariam Dabbous1,3,4
1School of Pharmacy, Lebanese International University, Beirut, Lebanon, liu.edu.lb.
International journal of nephrology
|January 1, 2026
概括
在血液透析患者中,利尿剂的使用是常见的,但往往不理想. 较高剂量的利尿剂,如furosemide与更好的临床结果有关,这表明需要在这个人群中优化剂量策略.
科学领域:
- 脏病学和泌尿病学 医学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 利尿剂对于管理血液透析患者的体积过载至关重要,但它们的使用是不一致的.
- 了解利尿剂的使用模式及其对临床结果的影响对于改善患者护理至关重要.
研究的目的:
- 调查黎巴嫩血液透析患者的利尿剂使用模式.
- 为了比较使用利尿剂和不使用利尿剂的患者之间的临床结果.
- 在这个患者群体中确定预测尿液剂使用的因素.
主要方法:
- 一个多中心的回顾性观察性研究,涉及250名血液透析患者在黎巴嫩的8个中心.
- 数据收集包括社会人口统计,血液透析参数和临床结果.
- 统计分析包括描述性,双变量和多变量逻辑回归来评估关联.
主要成果:
- 38.4%的患者使用了利尿剂,主要是循环利尿剂,如furosemide,平均相当剂量为153.56毫克/天.
- 利尿剂使用者更有可能有残留功能,更短的透析年限和更高的透析后静脉血压.
- 较高的富洛塞米德等效剂量 (≥250 mg/天和≥320 mg/天) 与改善的结果有关,包括降低血压,干燥体重和更少的低血压发作.
结论:
- 尽管利尿剂的使用率很高,但在血液透析患者中,剂量似乎不足于最佳水平.
- 用户和非使用者之间的临床结果没有显著差异,但更高的剂量显示出好处.
- 需要进一步的研究来优化利尿剂剂量策略,以改善血液透析患者体积过载的管理.
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