相关实验视频
Updated: Jan 7, 2026

08:42
Myo-mechanical Analysis of Isolated Skeletal Muscle
Published on: February 22, 2011
27.4K
在静态和动态负载下对肌肉机械应力的多尺度分析
Xue Ke1,2, Yansong Lu1, Linjing Peng1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Biophysics reports
|January 1, 2026
概括
循环力刺激可以通过改变肌肉纤维的机械应力来预防深层组织损伤 (DTI). 特定的高频,低振幅力似乎可以减少破坏性应力,这表明对长时间的机械负荷有潜在的保护机制.
科学领域:
- 生物力学 生物力学
- 细胞力学 细胞力学
- 组织工程是组织工程.
背景情况:
- 深层组织损伤 (DTI) 是由于长时间的机械负荷造成的.
- 了解细胞和组织对循环力刺激的反应,对于预防DTI至关重要.
- 目前对DTI生物机械机制的了解有限.
研究的目的:
- 研究循环力传递对肌肉纤维的生物力学影响.
- 分析不同循环力参数 (频率,振幅) 对组织和细胞应激的影响.
- 探索使用多尺度建模减轻DTI的潜在策略.
主要方法:
- 利用一个多尺度的有限元模型来模拟循环力传输.
- 结合了肌肉组织和细胞的粘弹性特性.
- 在不同的循环力频率和振幅下分析了应力放松.
主要成果:
- 最大·米塞斯应力随着周期力振幅的增加而增加.
- 频率变化对宏观和美观模型的影响最小.
- 微观模型显示频率依赖的应力变化;高频/低振幅降低了应力.
结论:
- 高频低振幅循环力模式显示了减轻机械损坏的潜力.
- 这种特定的负载模式可能会延迟或防止深层组织损伤.
- 研究结果提供了通过受控机械刺激预防DTI的新策略的见解.
相关概念视频
Stress: General Loading Conditions
512
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes....
512
Stresses under Combined Loadings
416
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
416

