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在接受他类药物治疗的患有严重高胆固醇血症的患者中,先天性免疫细胞功能与正常胆固醇血症患者相似:一个横截面研究

Harsh Bahrar¹, Kim Steward², Liesbeth van Emst¹

¹Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Atherosclerosis plus

|January 1, 2026

概括

在患有严重高胆固醇血症的患者中,他类药物治疗使单细胞功能正常化,从而消除了先前观察到的高反应性先天免疫表型. 中性粒细胞功能也呈现正常化,蛋白质颗粒分泌量有所减少.

科学领域:

免疫学免疫学免疫学
心血管医学心血管医学
遗传学是一个遗传学.

背景情况:

高胆固醇血症是动脉样硬化心血管疾病的关键危险因素.
像单细胞和中性粒细胞这样的先天性免疫细胞与动脉样硬化发展有关.
以前的研究表明,在严重的高胆固醇血症中,即使在服用他类药物治疗后,也存在持续的高反应性单细胞表型 (训练免疫力).

研究的目的:

为了研究12个月的他类药物治疗对严重高胆固醇血症中单细胞和中性粒细胞表型的长期影响.
为了比较治疗患者的免疫细胞功能与正常胆固醇血清对照.

主要方法:

一项多中心的横截面研究包括12个月的他类药物治疗 (n=15) 后未接受过治疗的严重高胆固醇血症患者 (LDL-c>4.9 mmol/L).
与健康的正常胆固醇血清对照进行了比较 (LDL-c <3.5 mmol/L; n=18).
评估了单细胞表型,PBMC细胞因子生产,TNFA促进体上的H3K4me3,以及中性粒细胞表型/功能.

主要成果:

立方体治疗有效降低了LDL-c从5.8mmol/L降至2.7mmol/L.
单细胞细胞因子生产能力和TNFA促进体上的H3K4me3表达与对照组相似.
中性粒细胞的表型 (CD11b,CD66b,CD62L表达) 类似,但与对照组相比,颗粒蛋白质分泌量减少.

结论:

十二个月的他类药物治疗使之前在严重高胆固醇血症中观察到的高响应单细胞表型正常化.
与高的LDL-c相关的先天免疫记忆 (训练免疫) 似乎可以在持续的他类药物治疗下逆转.
虽然中性粒细胞表型正常化,但减少颗粒蛋白质分泌值得进一步调查.

关键词:

细胞因子的生产超高胆固醇血症是什么情况炎症炎症是一种炎症.天生的免疫细胞是天生的免疫细胞.降脂治疗可以降低脂质.类他类药物是一种药物.训练有素的免疫力

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