鉴定和验证与心力衰竭中尼古丁胺代谢通路活性相关的生物标志物
Jianping Du1, Xiaoyu Yang1, Shuxing Wu1
1Department of Cardiology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Frontiers in genetics
|January 1, 2026
概括
与尼古丁胺胺代谢 (NMN) 途径活性相关的新生物标志物NDC1,NUP133和TRMT11显示出对诊断和理解心力衰竭 (HF) 的前景. 这些发现为心血管功能障碍提供了潜在的治疗见解.
科学领域:
- 心血管生物学 心血管生物学
- 代谢途径 代谢途径
- 生物标志物发现发现
背景情况:
- 心力衰竭 (HF) 代表了心血管疾病的晚期阶段.
- 尼古丁胺胺代谢 (NMN) 与心血管功能障碍有关.
- 了解与HF中NMN通路活性 (NMRGs) 相关的基因至关重要.
研究的目的:
- 在心力衰竭中识别与NMN通路活性相关的基因.
- 为了验证HF诊断和病原发生的新生物标志物.
- 探索HF的潜在治疗点和诊断工具.
主要方法:
- 在公共数据库的高频数据上利用权重基因同表达网络分析 (WGCNA).
- 通过差异表达和模块分析选择候选基因.
- 使用PPI网络,机器学习和RT-qPCR识别和验证生物标志物 (NDC1,NUP133,TRMT11).
主要成果:
- 验证了NDC1,NUP133和TRMT11作为与HF中NMN相关的关键生物标志物.
- 开发了一个名图,证明了高HF的高诊断准确性.
- 鉴定了spliceosome和ubiquitin介导的蛋白解路径中的丰富性以及与中性粒细胞的相关性.
结论:
- 在高频率中,NDC1,NUP133和TRMT11作为新的NMN相关生物标志物.
- 这些生物标志物为HF病原体提供了有价值的见解.
- 研究结果表明,HF治疗和改善诊断的潜在途径.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516
01:30Heart Failure VII: Nursing Interventions
392
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
392
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:29Heart Failure II: Pathophysiology
663
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
663
01:30Heart Failure IV: Classification and Diagnostic Evaluation
290
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
290