臭氧灭菌:对电聚烯酸膜特性和细胞活性的影响
Taisa L S Farias1, Ivanildes Bastos1,2, Joelma Cavalcante Ricardo3,4
1Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil, ufam.edu.br.
International journal of biomaterials
|January 1, 2026
概括
臭氧灭菌有效地保护了电聚烯酸 (PCL) 膜,创造了生物相容的支架,非常适合组织工程和伤口愈合应用中的细胞生长.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 表面化学 表面化学
背景情况:
- 电聚烯酸 (PCL) 膜模仿细胞外基质,为细胞生长提供了潜力.
- 开发有效的灭菌方法对于PCL支架的生物医学应用至关重要.
研究的目的:
- 开发和表征臭氧灭菌电PCL膜用于细胞生长.
- 评估臭氧灭菌对PCL膜特性和生物相容性的影响.
主要方法:
- 通过电制造PCL膜.
- 在室温下对臭氧进行灭菌.
- 使用SEM,接触角度,UV-Vis,DSC,TGA,FTIR,拉曼光谱和体外细胞分析进行表征.
主要成果:
- 获得了统一的PCL纤维 (直径403±100nm).
- 臭氧灭菌确保了膜无菌性,而不会影响水性或化学完整性 (FTIR,Raman).
- 观察到高细胞活力 (>97%) 和粘附性,证实了生物相容性.
结论:
- 臭氧灭菌是PCL膜的有效方法,可以保持其结构和生物相容性.
- 电PCL膜是适合生物医学应用的支架,如组织工程和伤口愈合.
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