通过磁性触发的锁来实现目标有效载荷的输送和回收,结合了挂和无挂的磁性机器人
Michael Brockdorff1, Benjamin Calmé1, Tianlu Wang2,3
1STORM Lab, Institute of Autonomous Systems and Sensing (IRASS), School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK.
Science advances
|January 1, 2026
概括
No abstract available in PubMed .
相关概念视频
01:43SNAREs and Membrane Fusion
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Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
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01:25Rab Cascades
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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