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Vinit C Shanbhag1, Nikita Gudekar1, Muhammad Yasir2

  • 1Department of Biochemistry, Life Sciences Center, University of Missouri, Columbia, Missouri, USA.

medRxiv : the preprint server for health sciences
|January 2, 2026
PubMed
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No abstract available in PubMed .

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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