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Updated: Jan 7, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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基于Inavolisib的治疗PIK3CA突变的晚期男性乳腺癌:成本效益分析

Xiaoting Huang1,2, Shen Lin1,2, Rongfang Lin1,2

  • 1Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People's Republic of China.

Breast cancer (Dove Medical Press)
|January 2, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
有PIK3CA突变的经济效益其他药物男人的乳腺癌

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PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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