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Updated: May 10, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

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通过IMU-935对RORγt-CBFβ相互作用的选择性干扰可以阻止RORγt依赖的Th17自身免疫,但不能阻止胸细胞的发展

Hongmin Wu1, Xiancai Zhong1, Ning Ma2

  • 1Department of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute.

The Journal of clinical investigation
|January 2, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
自免疫性疾病自体免疫性药物治疗免疫学

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...