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Updated: Jun 19, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
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多原子分析揭示了与肠道α-synuclein聚合相关的分子途径

Julia M Balsamo1, Ying Yan2, Dylan Thai1

  • 1Department of Chemistry, University of California, Irvine, California 92617, United States.

ACS chemical biology
|January 2, 2026
PubMed
概括

No abstract available in PubMed .

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...