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Updated: May 2, 2026

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
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来自Brucella abortus的细菌胺的结构分析和抑制剂建模

Lijun Liu1,2, Elizabeth K Harmon2,3, Justin K Craig2,3

  • 1Protein Structure and X-Ray Crystallography Laboratory, Del Shankel Structural Biology Center, University of Kansas, Kansas, USA.

Proteins
|January 2, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
细菌化物菌病抑制剂的结合铁运输病原体蛋白质复合物

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Inhibitors of Bacterial Protein Synthesis01:25

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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
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