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Updated: Jun 18, 2026

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在人类iPSC衍生的神经元外移植中,Aβ斑块诱导局部前突触毒性

Jacqueline Fréderique Maria van Vierbergen1, Carles Calatayud1, Sriram Balusu1

  • 1VIB KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium.

Stem cell reports
|January 3, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
阿尔茨海默病粉样β斑块变质神经炎细胞外Aβ前突触突触毒性异种移植

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Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...