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Updated: Jan 7, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

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Published on: March 24, 2017

在小鼠中,NRF2的缺乏会加重BLM诱导的全身性硬化相关纤维化和炎症

Qianyu Zhu¹, Pan Guo², Ruotong Wang¹

¹Immunology Department, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin 300070, China.

International immunopharmacology

|January 4, 2026

概括

No abstract available in PubMed .

关键词:

炎症反应其他类型氧化应激系统性硬化

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NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...