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Updated: Jan 7, 2026

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

一个可诱导天然甜味剂的基因开关控制了哺乳动物的治疗蛋白质表达

Longliang Qiao¹, Zhihao Wang², Shasha Tang¹

¹Department of Breast Surgery, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 5, 2026

概括

No abstract available in PubMed .

关键词:

D-Psicose可乐的使用 PURE系统基于细胞的疗法基因交换

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Transgenic Organisms

Transgenic Organisms

The Central Dogma

The Central Dogma

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RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...

Reporter Genes

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.

Recombinant DNA

Recombinant DNA

In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.