暴露和儿童的神经发育障碍:一个横截面研究
Claudia López1, Paola Rubilar2, María P Muñoz3,4
1Programa de Magíster en Salud Pública, Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Annals of global health
|January 5, 2026
概括
来自Arica的儿童的暴露与神经发育障碍 (NDD) 的更高患病率有关,包括注意力缺陷多动症障碍 (ADHD) 和自闭症谱系障碍 (ASD). 尿水平升高表明这些发育条件的风险增加.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
背景情况:
- 暴露是神经发育障碍 (NDD) 的潜在危险因素.
- 在Arica之前的研究集中在和注意力缺陷多动症 (ADHD) 上,需要进一步调查其他NDD,如自闭症谱系障碍 (ASD).
研究的目的:
- 评估当前尿度与居住在阿里卡的儿童中NDD的患病率之间的关联.
- 探索暴露与特定的NDD,包括ADHD和ASD之间的关系.
主要方法:
- 一项采用FONIS项目的二次数据进行的横截面研究#SA22I0119.
- 涉及2013年至2016年间出生的450名儿童,NDD诊断是由父母自我报告决定的.
- 测量了尿液中无机的度,调整了肌素,并使用了逻辑回归分析,考虑了混变量.
主要成果:
- 患有ADHD的患病率为9.1%,ASD为5.3%,NDD的总体患病率为12%.
- 观察到尿液中无机的平均度为19.8μg/g,其中7.6%的儿童超过35μg/g.
- 尿含量≥35μg/g肌的儿童在调整混因子后显示,出现NDD (OR:2.93) 和ADHD (OR:3.85) 的可能性明显更高.
结论:
- 研究结果表明,暴露与儿童NDD的患病率之间存在显著的关联.
- 结果有助于越来越多的证据证明对儿童神经发育的有害影响.
- 强调需要采取公共卫生干预措施,以减轻弱势群体对的暴露.
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