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Updated: Jun 15, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
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Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

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在小鼠中的cGAS绝杀抑制的内毒素诱导性脑膜炎

Yue Guo1,2,3,4,5, Ruiping Gu1,2,3,4, Jiaojiao Wei1,2,3,4

  • 1Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.

Genes & diseases
|January 5, 2026
PubMed
概括

No abstract available in PubMed .

关键词:
没有.脂聚糖类视网膜一个cGAS 公司

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GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of cells.
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